An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
Identifieur interne : 001488 ( Main/Exploration ); précédent : 001487; suivant : 001489An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
Auteurs : Stefano Bonassi [Italie] ; Ariana Znaor [Croatie] ; Marcello Ceppi [Italie] ; Cecilia Lando [Italie] ; Wushou Peter Chang [Taïwan] ; Nina Holland [États-Unis] ; Micheline Kirsch-Volders [Belgique] ; Errol Zeiger [États-Unis] ; Sadayuki Ban [Japon] ; Roberto Barale [Italie] ; Maria Paola Bigatti [Italie] ; Claudia Bolognesi [Italie] ; Antonina Cebulska-Wasilewska [Pologne] ; Eleonora Fabianova [Slovaquie] ; Alexandra Fucic [Croatie] ; Lars Hagmar [Suède] ; Gordana Joksic [Yougoslavie] ; Antonietta Martelli [Italie] ; Lucia Migliore [Italie] ; Ekaterina Mirkova [Bulgarie] ; Maria Rosaria Scarfi [Italie] ; Andrea Zijno [Italie] ; Hannu Norppa [Finlande] ; Michael Fenech [Australie]Source :
- Carcinogenesis [ 0143-3334 ] ; 2006-09-14.
Abstract
The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker of chromosomal damage and genome stability in human populations. Much theoretical evidence has been accumulated supporting the causal role of MN induction in cancer development, although prospective cohort studies are needed to validate MN as a cancer risk biomarker. A total of 6718 subjects from of 10 countries, screened in 20 laboratories for MN frequency between 1980 and 2002 in ad hoc studies or routine cytogenetic surveillance, were selected from the database of the HUman MicroNucleus (HUMN) international collaborative project and followed up for cancer incidence or mortality. To standardize for the inter-laboratory variability subjects were classified according to the percentiles of MN distribution within each laboratory as low, medium or high frequency. A significant increase of all cancers incidence was found for subjects in the groups with medium (RR = 1.84; 95% CI: 1.28–2.66) and high MN frequency (RR = 1.53; 1.04–2.25). The same groups also showed a decreased cancer-free survival, i.e. P = 0.001 and P = 0.025, respectively. This association was present in all national cohorts and for all major cancer sites, especially urogenital (RR = 2.80; 1.17–6.73) and gastro-intestinal cancers (RR = 1.74; 1.01–4.71). The results from the present study provide preliminary evidence that MN frequency in PBL is a predictive biomarker of cancer risk within a population of healthy subjects. The current wide-spread use of the MN assay provides a valuable opportunity to apply this assay in the planning and validation of cancer surveillance and prevention programs.
Url:
DOI: 10.1093/carcin/bgl177
Affiliations:
- Australie, Belgique, Bulgarie, Croatie, Finlande, Italie, Japon, Pologne, Slovaquie, Suède, Taïwan, Yougoslavie, États-Unis
- Californie
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000E71
- to stream Istex, to step Curation: 000E62
- to stream Istex, to step Checkpoint: 000F51
- to stream Main, to step Merge: 001495
- to stream Main, to step Curation: 001488
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans</title><author><name sortKey="Bonassi, Stefano" sort="Bonassi, Stefano" uniqKey="Bonassi S" first="Stefano" last="Bonassi">Stefano Bonassi</name></author><author><name sortKey="Znaor, Ariana" sort="Znaor, Ariana" uniqKey="Znaor A" first="Ariana" last="Znaor">Ariana Znaor</name></author><author><name sortKey="Ceppi, Marcello" sort="Ceppi, Marcello" uniqKey="Ceppi M" first="Marcello" last="Ceppi">Marcello Ceppi</name></author><author><name sortKey="Lando, Cecilia" sort="Lando, Cecilia" uniqKey="Lando C" first="Cecilia" last="Lando">Cecilia Lando</name></author><author><name sortKey="Chang, Wushou Peter" sort="Chang, Wushou Peter" uniqKey="Chang W" first="Wushou Peter" last="Chang">Wushou Peter Chang</name></author><author><name sortKey="Holland, Nina" sort="Holland, Nina" uniqKey="Holland N" first="Nina" last="Holland">Nina Holland</name></author><author><name sortKey="Kirsch Volders, Micheline" sort="Kirsch Volders, Micheline" uniqKey="Kirsch Volders M" first="Micheline" last="Kirsch-Volders">Micheline Kirsch-Volders</name></author><author><name sortKey="Zeiger, Errol" sort="Zeiger, Errol" uniqKey="Zeiger E" first="Errol" last="Zeiger">Errol Zeiger</name></author><author><name sortKey="Ban, Sadayuki" sort="Ban, Sadayuki" uniqKey="Ban S" first="Sadayuki" last="Ban">Sadayuki Ban</name></author><author><name sortKey="Barale, Roberto" sort="Barale, Roberto" uniqKey="Barale R" first="Roberto" last="Barale">Roberto Barale</name></author><author><name sortKey="Bigatti, Maria Paola" sort="Bigatti, Maria Paola" uniqKey="Bigatti M" first="Maria Paola" last="Bigatti">Maria Paola Bigatti</name></author><author><name sortKey="Bolognesi, Claudia" sort="Bolognesi, Claudia" uniqKey="Bolognesi C" first="Claudia" last="Bolognesi">Claudia Bolognesi</name></author><author><name sortKey="Cebulska Wasilewska, Antonina" sort="Cebulska Wasilewska, Antonina" uniqKey="Cebulska Wasilewska A" first="Antonina" last="Cebulska-Wasilewska">Antonina Cebulska-Wasilewska</name></author><author><name sortKey="Fabianova, Eleonora" sort="Fabianova, Eleonora" uniqKey="Fabianova E" first="Eleonora" last="Fabianova">Eleonora Fabianova</name></author><author><name sortKey="Fucic, Alexandra" sort="Fucic, Alexandra" uniqKey="Fucic A" first="Alexandra" last="Fucic">Alexandra Fucic</name></author><author><name sortKey="Hagmar, Lars" sort="Hagmar, Lars" uniqKey="Hagmar L" first="Lars" last="Hagmar">Lars Hagmar</name></author><author><name sortKey="Joksic, Gordana" sort="Joksic, Gordana" uniqKey="Joksic G" first="Gordana" last="Joksic">Gordana Joksic</name></author><author><name sortKey="Martelli, Antonietta" sort="Martelli, Antonietta" uniqKey="Martelli A" first="Antonietta" last="Martelli">Antonietta Martelli</name></author><author><name sortKey="Migliore, Lucia" sort="Migliore, Lucia" uniqKey="Migliore L" first="Lucia" last="Migliore">Lucia Migliore</name></author><author><name sortKey="Mirkova, Ekaterina" sort="Mirkova, Ekaterina" uniqKey="Mirkova E" first="Ekaterina" last="Mirkova">Ekaterina Mirkova</name></author><author><name sortKey="Scarfi, Maria Rosaria" sort="Scarfi, Maria Rosaria" uniqKey="Scarfi M" first="Maria Rosaria" last="Scarfi">Maria Rosaria Scarfi</name></author><author><name sortKey="Zijno, Andrea" sort="Zijno, Andrea" uniqKey="Zijno A" first="Andrea" last="Zijno">Andrea Zijno</name></author><author><name sortKey="Norppa, Hannu" sort="Norppa, Hannu" uniqKey="Norppa H" first="Hannu" last="Norppa">Hannu Norppa</name></author><author><name sortKey="Fenech, Michael" sort="Fenech, Michael" uniqKey="Fenech M" first="Michael" last="Fenech">Michael Fenech</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:ED32B33CBEA0F140526BE0C260DE7C14D34638EF</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1093/carcin/bgl177</idno><idno type="url">https://api.istex.fr/document/ED32B33CBEA0F140526BE0C260DE7C14D34638EF/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000E71</idno><idno type="wicri:Area/Istex/Curation">000E62</idno><idno type="wicri:Area/Istex/Checkpoint">000F51</idno><idno type="wicri:doubleKey">0143-3334:2007:Bonassi S:an:increased:micronucleus</idno><idno type="wicri:Area/Main/Merge">001495</idno><idno type="wicri:Area/Main/Curation">001488</idno><idno type="wicri:Area/Main/Exploration">001488</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans</title><author><name sortKey="Bonassi, Stefano" sort="Bonassi, Stefano" uniqKey="Bonassi S" first="Stefano" last="Bonassi">Stefano Bonassi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Molecular Epidemiology, National Cancer Research Institute Genoa</wicri:regionArea><wicri:noRegion>National Cancer Research Institute Genoa</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Italie</country></affiliation></author><author><name sortKey="Znaor, Ariana" sort="Znaor, Ariana" uniqKey="Znaor A" first="Ariana" last="Znaor">Ariana Znaor</name><affiliation wicri:level="1"><country xml:lang="fr">Croatie</country><wicri:regionArea>Croatian National Cancer Registry, Croatian National Institute of Public Health Zagreb</wicri:regionArea><wicri:noRegion>Croatian National Institute of Public Health Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Ceppi, Marcello" sort="Ceppi, Marcello" uniqKey="Ceppi M" first="Marcello" last="Ceppi">Marcello Ceppi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Molecular Epidemiology, National Cancer Research Institute Genoa</wicri:regionArea><wicri:noRegion>National Cancer Research Institute Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Lando, Cecilia" sort="Lando, Cecilia" uniqKey="Lando C" first="Cecilia" last="Lando">Cecilia Lando</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Molecular Epidemiology, National Cancer Research Institute Genoa</wicri:regionArea><wicri:noRegion>National Cancer Research Institute Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Wushou Peter" sort="Chang, Wushou Peter" uniqKey="Chang W" first="Wushou Peter" last="Chang">Wushou Peter Chang</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Environmental Health Sciences, National Yang Ming University Medical School Taipei</wicri:regionArea><wicri:noRegion>National Yang Ming University Medical School Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Holland, Nina" sort="Holland, Nina" uniqKey="Holland N" first="Nina" last="Holland">Nina Holland</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>School of Public Health, University of California Berkeley, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kirsch Volders, Micheline" sort="Kirsch Volders, Micheline" uniqKey="Kirsch Volders M" first="Micheline" last="Kirsch-Volders">Micheline Kirsch-Volders</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory for Cell Genetics, Vrije Universiteit Brussel Brussel</wicri:regionArea><wicri:noRegion>Vrije Universiteit Brussel Brussel</wicri:noRegion></affiliation></author><author><name sortKey="Zeiger, Errol" sort="Zeiger, Errol" uniqKey="Zeiger E" first="Errol" last="Zeiger">Errol Zeiger</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Errol Zeiger Consulting, Chapel Hill NC</wicri:regionArea><wicri:noRegion>Chapel Hill NC</wicri:noRegion></affiliation></author><author><name sortKey="Ban, Sadayuki" sort="Ban, Sadayuki" uniqKey="Ban S" first="Sadayuki" last="Ban">Sadayuki Ban</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation Hiroshima</wicri:regionArea><wicri:noRegion>Radiation Effects Research Foundation Hiroshima</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Present address: National Institute of Radiological Sciences</wicri:regionArea></affiliation></author><author><name sortKey="Barale, Roberto" sort="Barale, Roberto" uniqKey="Barale R" first="Roberto" last="Barale">Roberto Barale</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze dell'Uomo e dell'Ambiente, University of Pisa Pisa</wicri:regionArea><wicri:noRegion>University of Pisa Pisa</wicri:noRegion></affiliation></author><author><name sortKey="Bigatti, Maria Paola" sort="Bigatti, Maria Paola" uniqKey="Bigatti M" first="Maria Paola" last="Bigatti">Maria Paola Bigatti</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Biologia Animale, University of Turin Turin</wicri:regionArea><wicri:noRegion>University of Turin Turin</wicri:noRegion></affiliation></author><author><name sortKey="Bolognesi, Claudia" sort="Bolognesi, Claudia" uniqKey="Bolognesi C" first="Claudia" last="Bolognesi">Claudia Bolognesi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Unit of Environmental Carcinogenesis, National Cancer Research Institute Genoa</wicri:regionArea><wicri:noRegion>National Cancer Research Institute Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Cebulska Wasilewska, Antonina" sort="Cebulska Wasilewska, Antonina" uniqKey="Cebulska Wasilewska A" first="Antonina" last="Cebulska-Wasilewska">Antonina Cebulska-Wasilewska</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College Kraków</wicri:regionArea><wicri:noRegion>Jagiellonian University Medical College Kraków</wicri:noRegion></affiliation></author><author><name sortKey="Fabianova, Eleonora" sort="Fabianova, Eleonora" uniqKey="Fabianova E" first="Eleonora" last="Fabianova">Eleonora Fabianova</name><affiliation wicri:level="1"><country xml:lang="fr">Slovaquie</country><wicri:regionArea>State Health Institute</wicri:regionArea></affiliation></author><author><name sortKey="Fucic, Alexandra" sort="Fucic, Alexandra" uniqKey="Fucic A" first="Alexandra" last="Fucic">Alexandra Fucic</name><affiliation wicri:level="1"><country xml:lang="fr">Croatie</country><wicri:regionArea>Institute for Medical Research and Occupational Health</wicri:regionArea></affiliation></author><author><name sortKey="Hagmar, Lars" sort="Hagmar, Lars" uniqKey="Hagmar L" first="Lars" last="Hagmar">Lars Hagmar</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Occupational and Environmental Medicine, Lund University Lund</wicri:regionArea><wicri:noRegion>Lund University Lund</wicri:noRegion></affiliation></author><author><name sortKey="Joksic, Gordana" sort="Joksic, Gordana" uniqKey="Joksic G" first="Gordana" last="Joksic">Gordana Joksic</name><affiliation wicri:level="1"><country xml:lang="fr">Yougoslavie</country><wicri:regionArea>Vinca Institute of Nuclear Sciences, Medical Protection Centre Belgrade</wicri:regionArea><wicri:noRegion>Medical Protection Centre Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Martelli, Antonietta" sort="Martelli, Antonietta" uniqKey="Martelli A" first="Antonietta" last="Martelli">Antonietta Martelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>DIMI, University of Genoa Genoa</wicri:regionArea><wicri:noRegion>University of Genoa Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Migliore, Lucia" sort="Migliore, Lucia" uniqKey="Migliore L" first="Lucia" last="Migliore">Lucia Migliore</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze dell'Uomo e dell'Ambiente, University of Pisa Pisa</wicri:regionArea><wicri:noRegion>University of Pisa Pisa</wicri:noRegion></affiliation></author><author><name sortKey="Mirkova, Ekaterina" sort="Mirkova, Ekaterina" uniqKey="Mirkova E" first="Ekaterina" last="Mirkova">Ekaterina Mirkova</name><affiliation wicri:level="1"><country xml:lang="fr">Bulgarie</country><wicri:regionArea>National Center of Public Health Protection</wicri:regionArea></affiliation></author><author><name sortKey="Scarfi, Maria Rosaria" sort="Scarfi, Maria Rosaria" uniqKey="Scarfi M" first="Maria Rosaria" last="Scarfi">Maria Rosaria Scarfi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>CNR-IREA</wicri:regionArea></affiliation></author><author><name sortKey="Zijno, Andrea" sort="Zijno, Andrea" uniqKey="Zijno A" first="Andrea" last="Zijno">Andrea Zijno</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Environment and Primary Prevention, Istituto Superiore di Sanità Rome</wicri:regionArea><wicri:noRegion>Istituto Superiore di Sanità Rome</wicri:noRegion></affiliation></author><author><name sortKey="Norppa, Hannu" sort="Norppa, Hannu" uniqKey="Norppa H" first="Hannu" last="Norppa">Hannu Norppa</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>New Technologies and Risks, Finnish Institute of Occupational Health Helsinki</wicri:regionArea><wicri:noRegion>Finnish Institute of Occupational Health Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Fenech, Michael" sort="Fenech, Michael" uniqKey="Fenech M" first="Michael" last="Fenech">Michael Fenech</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Human Nutrition</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Carcinogenesis</title><idno type="ISSN">0143-3334</idno><idno type="eISSN">1460-2180</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2006-09-14">2006-09-14</date><biblScope unit="volume">28</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="625">625</biblScope><biblScope unit="page" to="631">631</biblScope></imprint><idno type="ISSN">0143-3334</idno></series><idno type="istex">ED32B33CBEA0F140526BE0C260DE7C14D34638EF</idno><idno type="DOI">10.1093/carcin/bgl177</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0143-3334</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker of chromosomal damage and genome stability in human populations. Much theoretical evidence has been accumulated supporting the causal role of MN induction in cancer development, although prospective cohort studies are needed to validate MN as a cancer risk biomarker. A total of 6718 subjects from of 10 countries, screened in 20 laboratories for MN frequency between 1980 and 2002 in ad hoc studies or routine cytogenetic surveillance, were selected from the database of the HUman MicroNucleus (HUMN) international collaborative project and followed up for cancer incidence or mortality. To standardize for the inter-laboratory variability subjects were classified according to the percentiles of MN distribution within each laboratory as low, medium or high frequency. A significant increase of all cancers incidence was found for subjects in the groups with medium (RR = 1.84; 95% CI: 1.28–2.66) and high MN frequency (RR = 1.53; 1.04–2.25). The same groups also showed a decreased cancer-free survival, i.e. P = 0.001 and P = 0.025, respectively. This association was present in all national cohorts and for all major cancer sites, especially urogenital (RR = 2.80; 1.17–6.73) and gastro-intestinal cancers (RR = 1.74; 1.01–4.71). The results from the present study provide preliminary evidence that MN frequency in PBL is a predictive biomarker of cancer risk within a population of healthy subjects. The current wide-spread use of the MN assay provides a valuable opportunity to apply this assay in the planning and validation of cancer surveillance and prevention programs.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Bulgarie</li><li>Croatie</li><li>Finlande</li><li>Italie</li><li>Japon</li><li>Pologne</li><li>Slovaquie</li><li>Suède</li><li>Taïwan</li><li>Yougoslavie</li><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="Italie"><noRegion><name sortKey="Bonassi, Stefano" sort="Bonassi, Stefano" uniqKey="Bonassi S" first="Stefano" last="Bonassi">Stefano Bonassi</name></noRegion><name sortKey="Barale, Roberto" sort="Barale, Roberto" uniqKey="Barale R" first="Roberto" last="Barale">Roberto Barale</name><name sortKey="Bigatti, Maria Paola" sort="Bigatti, Maria Paola" uniqKey="Bigatti M" first="Maria Paola" last="Bigatti">Maria Paola Bigatti</name><name sortKey="Bolognesi, Claudia" sort="Bolognesi, Claudia" uniqKey="Bolognesi C" first="Claudia" last="Bolognesi">Claudia Bolognesi</name><name sortKey="Bonassi, Stefano" sort="Bonassi, Stefano" uniqKey="Bonassi S" first="Stefano" last="Bonassi">Stefano Bonassi</name><name sortKey="Ceppi, Marcello" sort="Ceppi, Marcello" uniqKey="Ceppi M" first="Marcello" last="Ceppi">Marcello Ceppi</name><name sortKey="Lando, Cecilia" sort="Lando, Cecilia" uniqKey="Lando C" first="Cecilia" last="Lando">Cecilia Lando</name><name sortKey="Martelli, Antonietta" sort="Martelli, Antonietta" uniqKey="Martelli A" first="Antonietta" last="Martelli">Antonietta Martelli</name><name sortKey="Migliore, Lucia" sort="Migliore, Lucia" uniqKey="Migliore L" first="Lucia" last="Migliore">Lucia Migliore</name><name sortKey="Scarfi, Maria Rosaria" sort="Scarfi, Maria Rosaria" uniqKey="Scarfi M" first="Maria Rosaria" last="Scarfi">Maria Rosaria Scarfi</name><name sortKey="Zijno, Andrea" sort="Zijno, Andrea" uniqKey="Zijno A" first="Andrea" last="Zijno">Andrea Zijno</name></country><country name="Croatie"><noRegion><name sortKey="Znaor, Ariana" sort="Znaor, Ariana" uniqKey="Znaor A" first="Ariana" last="Znaor">Ariana Znaor</name></noRegion><name sortKey="Fucic, Alexandra" sort="Fucic, Alexandra" uniqKey="Fucic A" first="Alexandra" last="Fucic">Alexandra Fucic</name></country><country name="Taïwan"><noRegion><name sortKey="Chang, Wushou Peter" sort="Chang, Wushou Peter" uniqKey="Chang W" first="Wushou Peter" last="Chang">Wushou Peter Chang</name></noRegion></country><country name="États-Unis"><region name="Californie"><name sortKey="Holland, Nina" sort="Holland, Nina" uniqKey="Holland N" first="Nina" last="Holland">Nina Holland</name></region><name sortKey="Zeiger, Errol" sort="Zeiger, Errol" uniqKey="Zeiger E" first="Errol" last="Zeiger">Errol Zeiger</name></country><country name="Belgique"><noRegion><name sortKey="Kirsch Volders, Micheline" sort="Kirsch Volders, Micheline" uniqKey="Kirsch Volders M" first="Micheline" last="Kirsch-Volders">Micheline Kirsch-Volders</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Ban, Sadayuki" sort="Ban, Sadayuki" uniqKey="Ban S" first="Sadayuki" last="Ban">Sadayuki Ban</name></noRegion><name sortKey="Ban, Sadayuki" sort="Ban, Sadayuki" uniqKey="Ban S" first="Sadayuki" last="Ban">Sadayuki Ban</name></country><country name="Pologne"><noRegion><name sortKey="Cebulska Wasilewska, Antonina" sort="Cebulska Wasilewska, Antonina" uniqKey="Cebulska Wasilewska A" first="Antonina" last="Cebulska-Wasilewska">Antonina Cebulska-Wasilewska</name></noRegion></country><country name="Slovaquie"><noRegion><name sortKey="Fabianova, Eleonora" sort="Fabianova, Eleonora" uniqKey="Fabianova E" first="Eleonora" last="Fabianova">Eleonora Fabianova</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Hagmar, Lars" sort="Hagmar, Lars" uniqKey="Hagmar L" first="Lars" last="Hagmar">Lars Hagmar</name></noRegion></country><country name="Yougoslavie"><noRegion><name sortKey="Joksic, Gordana" sort="Joksic, Gordana" uniqKey="Joksic G" first="Gordana" last="Joksic">Gordana Joksic</name></noRegion></country><country name="Bulgarie"><noRegion><name sortKey="Mirkova, Ekaterina" sort="Mirkova, Ekaterina" uniqKey="Mirkova E" first="Ekaterina" last="Mirkova">Ekaterina Mirkova</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Norppa, Hannu" sort="Norppa, Hannu" uniqKey="Norppa H" first="Hannu" last="Norppa">Hannu Norppa</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Fenech, Michael" sort="Fenech, Michael" uniqKey="Fenech M" first="Michael" last="Fenech">Michael Fenech</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001488 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001488 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Belgique
|area= OpenAccessBelV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:ED32B33CBEA0F140526BE0C260DE7C14D34638EF
|texte= An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
}}
| This area was generated with Dilib version V0.6.25. |  |